Lutetium-177 (Lu-177) – Stable Isotope Data & Safety Information (MSDS)

SECTION 1: Lutetium-177 (Lu-177) – IDENTIFICATION

Product Name: Lutetium-177 (Lu-177)

Chemical Formula: Lu

CAS Number: 15080-66-7

Molecular Weight: 176.9437581 g/mol

Synonyms: Lu-177 isotope, Radioisotope Lutetium-177, Lu177 chloride, Lu-177 DOTATATE

Intended Use: Medical applications (radiopharmaceutical therapy), nuclear medicine, cancer treatment (e.g., neuroendocrine tumors), laboratory research

Manufacturer/Supplier Information:

• Company Name: Nakima Ltd
• Telephone: +971-52-5156232
• Website: www.isotope-amt.com

SECTION 2: HAZARD IDENTIFICATION

Classification of the substance or mixture

Classification according to Regulation (EC) No. 1272/2008 [CLP]

• Radioactive material – Regulated separately under radiation protection laws

Classification according to Directive 67/548/EEC [DSD] or 1999/45/EC [DPD]

• Not classified

GHS-US classification

• Not classified under GHS (due to radioactive nature)

Signal Word: Warning (radioactive material)

Hazard Statements:

• This product emits ionizing radiation
• Handle only by trained personnel using proper shielding and monitoring

Precautionary Statements:

• P201: Obtain special instructions before use
• P202: Do not handle until all safety precautions have been read
• P261: Avoid breathing dust/vapor/radiation exposure

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

SECTION 4: FIRST AID MEASURES

• Inhalation: Move to fresh air. Seek immediate medical assistance. Monitor for radiation exposure.
• Skin Contact: Remove contaminated clothing and wash thoroughly with soap and water.
• Eye Contact: Rinse with water for at least 15 minutes. Seek medical attention.
• Ingestion: Do not induce vomiting. Seek immediate medical attention. Follow radiological emergency protocol.

SECTION 5: FIRE-FIGHTING MEASURES

• Suitable Extinguishing Media: Use suitable extinguishing media for surrounding fire
• Unsuitable Extinguishing Media: None known
• Hazardous Combustion Products: May include radioactive particulates
• Protective Equipment for Firefighters: Wear full protective gear and SCBA. Radiation shielding may be required.

SECTION 6: ACCIDENTAL RELEASE MEASURES

• Personal Precautions: Evacuate area. Use protective clothing and radiation shielding
• Environmental Precautions: Prevent spread of contamination
• Cleanup Methods: Follow institutional radiological spill procedures. Use absorbent materials and radiation detectors

SECTION 7: HANDLING AND STORAGE

• Handling: Trained personnel only. Use in designated radiological areas with monitoring
• Storage Conditions: Store in shielded containers. Comply with legal radiation storage limits and labeling

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

• Occupational Exposure Limits: Follow local radiation protection regulations
• Engineering Controls: Shielding, radiation monitoring equipment
• Personal Protective Equipment (PPE):
  • Eye Protection: Safety goggles
  • Skin Protection: Radiation-rated gloves, lab coat
  • Respiratory Protection: Not typically required in sealed radiopharmaceuticals; use if risk of aerosolization

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

• Appearance: Colorless to light yellow liquid (in chloride form)
• Odor: Odorless
• Melting Point: Not applicable (used in solution)
• Boiling Point: Not applicable
• Solubility: Soluble (typically in saline or HCl)
• Density: Depends on formulation
• Autoignition Temperature: Not applicable

SECTION 10: STABILITY AND REACTIVITY

• Reactivity: Stable when stored and handled properly
• Chemical Stability: Stable under normal storage
• Incompatible Materials: Strong oxidizers, acids/bases (depending on formulation)
• Hazardous Decomposition Products: May emit radioactive dust if decomposed

SECTION 11: TOXICOLOGICAL INFORMATION

• Acute Toxicity: Radiotoxic — exposure must be minimized
• Carcinogenicity: Ionizing radiation may pose carcinogenic risk with prolonged exposure
• Routes of Exposure: Inhalation, ingestion, injection, skin contact (if unsealed)
• Symptoms: Potential for radiation burns, tissue damage, systemic effects

SECTION 12: ECOLOGICAL INFORMATION

• Ecotoxicity: Avoid release to the environment — radioactive contamination risk
• Persistence and Degradability: Not biodegradable
• Bioaccumulative Potential: May accumulate in bones and organs if absorbed
• Mobility in Soil: Depends on form; generally mobile as ionic compound

SECTION 13: DISPOSAL CONSIDERATIONS

Dispose of radioactive material per institutional, national, and IAEA guidelines. Requires licensed radioactive waste disposal.

SECTION 14: TRANSPORT INFORMATION

• UN Number: UN2915 (for radioactive material, Type A package)
• Proper Shipping Name: Radioactive material, Type A package, non-fissile
• Transport Hazard Class: 7 (Radioactive)
• Packing Group: Not applicable

SECTION 15: REGULATORY INFORMATION

• EU Regulations: Subject to radiation protection and transport laws
• US NRC/DOE Regulations: Applicable
• OSHA Hazard Classification: Radioactive material

SECTION 16: OTHER INFORMATION

Disclaimer: This information is provided in good faith for guidance only. Handling of Lu-177 must comply with radiation safety regulations and be performed by qualified personnel only.

Revision Date: March 2025

Prepared by: Nakima Ltd